COVID-19: Providers

Outpatient Therapeutics

Antivirals work by targeting specific proteins on the SARS-CoV-2 virus to prevent virus replication within the host cell.

The oral antivirals nirmatrelvir with ritonavir (Paxlovid), molnupiravir (Lagevrio) and the intravenous antiviral remdesivir (Veklury) are available for:

  • Treatment of symptomatic patients with mild to moderate COVID-19 who are at high risk of progressing to severe COVID-19.
  • Treatment must be started as soon as possible and within 5 to 7 days of symptom onset.

Preferred therapies:

  • Paxlovid is the preferred treatment for most outpatients 12 years or older.
  • IV remdesivir (Veklury) can be used if Paxlovid is contraindicated or in children younger than 12 years old.
    • For IV remdesivir, patients can visit ExpressCare for a treatment evaluation and to schedule an infusion appointment through NYC Health + Hospitals.
  • Molnupiravir (Lagevrio) is authorized as an alternative treatment option when Paxlovid and remdesivir are not accessible or clinically appropriate.

Pre-exposure prophylaxis:

  • Pemivibart (Pemgarda) is a monoclonal antibody available for pre-exposure prophylaxis under Emergency Use Authorization for some people who are moderately or severely immuno-compromised. Pemivibart does not replace vaccination against COVID-19.

For more details on outpatient treatments and pre-exposure prophylaxis, go to the Infectious Diseases Society of America COVID-19 Treatment Guidelines.

Coverage and Access

Patients may have out-of-pocket costs for oral antiviral medications. Patient assistance programs help ensure uninsured and underinsured individuals have continued and timely access to critical COVID-19 oral antivirals treatments. (See section Patient Assistance Programs below.)

Advise patients to call ahead to confirm availability of the medication at their pharmacy and whether there will be co-pays or other charges and direct them to the patient assistance programs to avoid unnecessary costs or delays in treatment.

Patients who do not have a health provider or are uninsured can be referred to:

  • NYC Health + Hospitals ExpressCare (212-COVID19 or 212-268-4319) for low- or no-cost treatment and care, including IV remdesivir if indicated for patients unable to take Paxlovid. Patients who do not have insurance or cannot afford to pay will be connected to financial counselors who can help them enroll in health insurance or financial assistance to reduce or eliminate their out-of-pocket costs. The standard self-pay charge for Virtual ExpressCare telehealth visits is $125.

Patient Assistance Programs

Counsel your patients on these programs when prescribing antivirals and help them enroll or provide them with the necessary information to do so to avoid unnecessary costs or delays in treatment.

Nirmatrelvir/Ritonavir (Paxlovid) Coverage and Access Programs

Find provider resources and patient education materials at Pfizer: Paxlovid Access.

Uninsured and Medicare/Tricare (through 2025)

  • Patients must enroll in Pfizer’s Paxcess Patient Assistance Program before picking up their prescription to avoid out-of-pocket costs.
  • To enroll, the patient, caregiver, provider or pharmacist can visit PAXCESS Patient Portal or call 877-C19-PACK (877-219-7225) to complete a short application.
  • Once approved, information will be provided on how and where to pick up the prescription. Prescriptions must be filled at a Paxcess participating pharmacy, which can be found at the Paxcess website.
  • Patients will not be reimbursed for out-of-pocket costs if they do not enroll in the Paxcess program.
  • Patients also have the option to request overnight mailing of the prescription via FedEx (Sundays excluded) by calling 877-219-7225.

Medicaid/CHIP

Commercial Insurance

  • Most commercially insured patients are eligible for co-pay assistance via Pfizer’s Co-Pay Savings Program.
  • Patients can go to Paxcess or call 877-219-7225 to enroll in the Co-Pay Savings Program before picking up the prescription at any pharmacy (not limited to pharmacies enrolled in Pfizer’s Paxcess program).
  • Patients who have already paid a co-pay for Paxlovid may be eligible for a reimbursement. Information and forms are available at Paxcess.

Molnupiravir (Lagevrio) Coverage and Access Programs

Since molnupiravir (Lagevrio) is only authorized under an Emergency Use Authorization, some health plans, including Medicaid, may not cover or will require prior authorization.

Uninsured or if Medication Not Covered by Health Plan

  • Merck has a Patient Assistance Program available for people without health insurance. Visit Merck Helps: Lagevrio for more information on eligibility.
  • To enroll patients in the program, a provider must call 800-727-5400 and tell the program representative that they are making an Urgent Need Request for Lagevrio for their patient. The program representative will provide further instructions.
  • If approved, Lagevrio will be shipped overnight to the patient’s address.

Medicaid

  • New York State Medicaid (NYRx) does not cover lagevrio.
  • Providers must call the Merck patient assistance program at 800-727-5400 to make a request on behalf of the patient (see above).

Medicare and Commercial Insurance

  • Lagevrio coverage varies. Patients should check with their pharmacy and health plan about coverage and co-payment costs. Prior authorization may be required.
  • Commercially insured patients may still be eligible for co-pay assistance. Visit Lagevrio: Coupon Offer to apply.
  • If a health plan does not cover Lagevrio or if the patient cannot afford the co-pay, insured patients may still qualify for the Patient Assistance Program if they attest to special circumstances of financial and medical hardship and their income meets program criteria. Providers should call 800-727-5400 to check eligibility.

Remdesivir (Veklury) Access Programs

Uninsured

  • For patients treated in the outpatient setting, a Patient Assistance Program is available for people without health insurance. Visit Gilead's Advancing Access Program or call 1-800-226-2056 for more information on eligibility.

Insured

Patient Education on Antivirals

People at increased risk of severe COVID-19 and their caregivers should be advised:

  • About the benefits of prompt oral antiviral treatment to reduce the risk of hospitalization and death
  • To immediately get tested if they develop COVID-19 symptoms or were recently exposed
  • To contact their provider right away if they test positive
  • That COVID-19 rebound is generally mild and does not represent a treatment failure or resistance

Resources for Patients

Resources for Providers