Each year in the U.S., 37,300 people get cancer caused by human papillomavirus (HPV). HPV vaccination is the most effective way to prevent these painful or deadly illnesses. HPV vaccine is recommended at ages 11–12, when HPV acquisition is low and the immune response to the vaccine is more robust. Unfortunately, New York City’s HPV vaccination rates fall dramatically short of the 2030 national goal of 80 percent for series completion. Health care providers play a critical role in increasing HPV vaccination rates, and this toolkit offers helpful strategies and tools.