Mpox: Vaccination

Getting vaccinated for mpox can reduce your chance of getting mpox, and it can reduce symptoms if you do get it.

Eligible New Yorkers can get the JYNNEOSTM vaccine.Contact your sexual health provider to see if they are offering the mpox vaccine. You can also find a vaccination site on the NYC Vaccine Finder.


You should get a second dose at least 28 days after your first dose.

It is important to get the second dose regardless of the amount of time that has passed since the first dose. You do not need to restart the two-dose vaccine series if your second dose is delayed.


The following people are eligible to be vaccinated in NYC:

  • People of any sexual orientation or gender identity who have or may have multiple or anonymous sex partners, or participate or may participate in group sex
  • People of any sexual orientation or gender identity whose sex partners are eligible per the criteria above
  • People who know or suspect they have been exposed to mpox in the last 14 days
  • Anyone else who considers themselves to be at risk for mpox through sex or other intimate contact.

People who are breastfeeding or pregnant who are otherwise eligible for vaccination can get vaccinated. For more information, see the JYNNEOS FAQ.

If you have had mpox, then you likely have some protection against another infection and are currently not eligible to get vaccinated. Most people who were diagnosed with mpox after getting their first dose of the vaccine do not need a second dose. People who are immunocompromised and have had mpox should speak with their provider about whether a second dose is necessary.

People with certain allergies to vaccine ingredients or chicken or egg protein should talk to a health care provider to confirm if they should get the vaccine. If you do not have a provider, call 311 or search the NYC Health Map.

Who Should Get Vaccinated

The JYNNEOS vaccine is recommended for people who meet the above eligibility criteria and:

  • Are men whose sex partners are men (cisgender or transgender), transgender women or gender nonconforming or nonbinary individuals; especially those who have been diagnosed with a sexually transmitted infection (STI) in the past 6 months
  • Are transgender, gender non-conforming or gender non-binary, especially those who have been diagnosed with an STI in the past 6 months
  • Are cisgender women whose sex partners are men who have sex with men or who are transgender, gender non-conforming or gender non-binary
  • Participate or may participate in sex parties or other events where there is minimal clothing and direct, frequent, or prolonged skin-to-skin contact
  • People who have had or anticipate having sex at a commercial sex venue or sex in association with a large public event
  • Are taking HIV pre-exposure prophylaxis (PrEP)
  • Are living with HIV
  • Sex workers, erotic workers and anyone engaging in survival sex or any other types of transactional sex (including sex in exchange for money, food, shelter or other goods) of any sexual orientation or gender identity

Side Effects

Common side effects of the JYNNEOS vaccine include tiredness, headache and muscle pain. There may also be redness, swelling, soreness and itchiness where you received the injection.