Mpox: Vaccination


Anyone of any sexual orientation or gender identity who is at risk for mpox can get vaccinated. See below for details, including recommendations on who should get vaccinated.

Minors ages 17 years and younger do not need parental consent to receive the vaccine.

First and Second Dose Appointments

If you are eligible, you can find a vaccination site by clicking on the button below. Contact your sexual health provider to see if they are also offering the vaccine.


You should get a second dose at least 28 days after your first dose.

You will start to build protection in the days and weeks after your first dose, but you will not have full immunity from the vaccine until two weeks after the second dose.

Getting vaccinated for mpox can reduce your chance of getting mpox, and it can reduce symptoms if you do get it. Eligible New Yorkers can get the JYNNEOSTM vaccine.


Vaccination is free and available regardless of immigration status.

The following people are eligible to be vaccinated in NYC:

  • People of any sexual orientation or gender identity who have or may have multiple or anonymous sex partners, or participate or may participate in group sex
  • People of any sexual orientation or gender identity whose sex partners are eligible per the criteria above
  • People who know or suspect they have been exposed to mpox in the last 14 days
  • Anyone else who considers themselves to be at risk for mpox through sex or other intimate contact.

People who are breastfeeding or pregnant who are otherwise eligible for vaccination can get vaccinated. For more information, see the JYNNEOS FAQ.

If you have had mpox, then you likely have some protection against another infection and are currently not eligible to get vaccinated. Most people who were diagnosed with mpox after getting their first dose of the vaccine do not need a second dose. People who are immunocompromised should speak with their provider about whether a second dose is necessary.

People with certain allergies to vaccine ingredients or chicken or egg protein should talk to a health care provider to confirm if they should get the vaccine. If you do not have a provider, call 311 or search the NYC Health Map.

Who Should Get Vaccinated

The JYNNEOS vaccine is recommended for people who meet the above eligibility criteria and:

  • Are men whose sex partners are men (cisgender or transgender), transgender women or gender nonconforming or nonbinary individuals; especially those who have been diagnosed with a sexually transmitted infection (STI) in the past 6 months
  • Are transgender, gender non-conforming or gender non-binary, especially those who have been diagnosed with an STI in the past 6 months
  • Are cisgender women whose sex partners are men who have sex with men or who are transgender, gender non-conforming or gender non-binary
  • Participate or may participate in sex parties or other events where there is minimal clothing and direct, frequent, or prolonged skin-to-skin contact
  • People who have had or anticipate having sex at a commercial sex venue or sex in association with a large public event
  • Are taking HIV pre-exposure prophylaxis (PrEP)
  • Are living with HIV
  • Sex workers, erotic workers and anyone engaging in survival sex or any other types of transactional sex (including sex in exchange for money, food, shelter or other goods) of any sexual orientation or gender identity

Getting Multiple Vaccines at Once

You can get the JYNNEOS vaccine at the same time as most vaccines, including the flu, human papilloma virus (HPV), hepatitis A, hepatitis B, meningococcal and herpes zoster (shingles) vaccines.

You can get the JYNNEOS vaccine before, after, or at the same time as COVID-19 vaccines too. However, people at increased risk of myocarditis (inflammation of the heart), particularly males ages 12 to 39, may consider waiting four weeks after getting the JYNNEOS vaccine to get a COVID-19 vaccine. This is because there is a rare risk of developing myocarditis after COVID-19 vaccination. While JYNNEOS clinical trials did not show an increased risk of myocarditis following vaccination, it is possible there is a risk.

If you know you were recently exposed to mpox, you should not delay getting the JYNNEOS vaccine.

For others, in deciding whether to delay getting either vaccine, consider your risk of exposure and risk of severe illness from COVID-19 and mpox. Talk to your health care provider if you have questions about timing of vaccination.

Side Effects

Common side effects of the JYNNEOS vaccine include tiredness, headache and muscle pain. There may also be redness, swelling, soreness and itchiness where you received the injection.

Additional Resources

  • Administration of the JYNNEOS Vaccine (PDF)
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